High-Protein Pizza Breakfast Casserole

Featured in: Weekend Rustic Recipes

This satisfying morning dish brings together the comforting flavors of pizza in a nutritious, high-protein format. The foundation is a simple Greek yogurt dough, rolled out and topped with pizza sauce before being layered with a fluffy egg and milk mixture. Generous portions of melted mozzarella and cheddar, along with turkey pepperoni and colorful vegetables, create that classic pizza taste while delivering 20 grams of protein per serving.

The preparation comes together in just 20 minutes of active time, then bakes until the eggs are set and the cheese is golden and bubbly. It's an excellent choice for meal prep, as you can assemble it the night before and bake it fresh in the morning. Each serving offers a balanced mix of protein, carbohydrates, and healthy fats to keep you satisfied throughout your morning.

Updated on Sun, 08 Feb 2026 14:02:20 GMT
Golden-brown High-Protein Pizza Breakfast Casserole, topped with turkey pepperoni and melted mozzarella, fresh from the oven. Save
Golden-brown High-Protein Pizza Breakfast Casserole, topped with turkey pepperoni and melted mozzarella, fresh from the oven. | olivebriar.com

Start your day with a flavorful twist on a classic favorite. This High-Protein Pizza Breakfast Casserole combines the savory satisfaction of pizza with a nutritious profile, making it a perfect addition to your breakfast rotation. With a base made from Greek yogurt dough and a topping of fluffy eggs and melted cheese, it is both hearty and delicious.

Golden-brown High-Protein Pizza Breakfast Casserole, topped with turkey pepperoni and melted mozzarella, fresh from the oven. Pin it
Golden-brown High-Protein Pizza Breakfast Casserole, topped with turkey pepperoni and melted mozzarella, fresh from the oven. | olivebriar.com

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This easy American-style casserole is ideal for meal prep, yielding six servings that can be enjoyed throughout the week. By using low-fat milk and part-skim mozzarella, you get all the comfort of a pizza breakfast with only 270 calories per serving.

Ingredients

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  • 1 cup (245 g) plain Greek yogurt (2% or 0% fat)
  • 1 cup (120 g) self-rising flour (plus extra for dusting)
  • 1/2 tsp garlic powder
  • 1/2 tsp dried oregano
  • 1/4 tsp salt
  • 6 large eggs
  • 1/2 cup (120 ml) low-fat milk
  • 1 cup (110 g) shredded mozzarella cheese, part-skim
  • 1/2 cup (50 g) shredded cheddar cheese
  • 1/2 cup (40 g) turkey pepperoni slices
  • 1/2 cup (125 ml) pizza sauce (low-sugar, if preferred)
  • 1/4 cup (25 g) diced bell pepper (optional)
  • 1/4 cup (25 g) diced red onion (optional)
  • 1 tbsp chopped fresh basil or parsley (optional, for garnish)
  • Salt and black pepper, to taste
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Instructions

Step 1
Preheat oven to 400°F (200°C). Lightly grease or line a rimmed sheet pan (approx. 9x13 inches) with parchment paper.
Step 2
In a medium bowl, combine Greek yogurt, self-rising flour, garlic powder, oregano, and salt. Mix until a shaggy dough forms. Knead briefly on a lightly floured surface until smooth, about 2–3 minutes.
Step 3
Roll or press dough into a rectangle to fit your prepared sheet pan. Transfer dough to pan and press evenly to the edges.
Step 4
Spread pizza sauce evenly over the dough base.
Step 5
In a large bowl, whisk together eggs, milk, a pinch of salt, and black pepper until well combined.
Step 6
Sprinkle half of the mozzarella and cheddar cheese over the pizza sauce.
Step 7
Pour the egg mixture evenly over the cheese.
Step 8
Top with turkey pepperoni, remaining cheese, bell pepper, and red onion (if using).
Step 9
Bake for 22–25 minutes, or until the eggs are set and cheese is golden and bubbly.
Step 10
Remove from oven. Let cool for 5 minutes, then garnish with fresh basil or parsley if desired. Slice and serve warm.

Zusatztipps für die Zubereitung

If you do not have self-rising flour, you can easily substitute it with 1 cup of all-purpose flour mixed with 1 1/2 teaspoons of baking powder and 1/4 teaspoon of salt. Ensure the dough is rolled thin enough to cover the sheet pan for a crispier crust.

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Varianten und Anpassungen

For a spicier kick, add red pepper flakes to the sauce or swap the turkey pepperoni for spicy turkey sausage. You can also experiment with different toppings like mushrooms or spinach to increase the vegetable content of your meal.

Serviervorschläge

This pizza casserole pairs beautifully with a simple green salad or a side of fresh fruit. It is best served warm directly after the five-minute cooling period to maintain the perfect cheese consistency.

Sliced serving of High-Protein Pizza Breakfast Casserole on a white plate, revealing fluffy eggs and cheesy layers. Pin it
Sliced serving of High-Protein Pizza Breakfast Casserole on a white plate, revealing fluffy eggs and cheesy layers. | olivebriar.com

Whether you're hosting a brunch or preparing your meals for the week, this High-Protein Pizza Breakfast Casserole is a convenient and satisfying choice. Slice it into squares and enjoy a high-protein start to your day that doesn't compromise on flavor.

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Frequently Asked Questions

Can I make this dish ahead of time?

Yes, you can assemble the entire dish the night before and refrigerate it. When ready to serve, simply bake as directed, adding a few extra minutes if baking from cold. This makes it perfect for busy mornings or meal prep.

What can I substitute for self-rising flour?

You can make your own self-rising flour by combining 1 cup all-purpose flour with 1½ teaspoons baking powder and ¼ teaspoon salt. This homemade version works perfectly in the Greek yogurt dough base.

How should I store leftovers?

Store leftover portions in an airtight container in the refrigerator for up to 3-4 days. Reheat individual slices in the microwave for 1-2 minutes or in a 350°F oven until warmed through.

Can I freeze this breakfast bake?

Yes, this freezes well. Cut into individual portions, wrap tightly in plastic wrap and foil, then freeze for up to 2 months. Thaw overnight in the refrigerator before reheating.

What vegetables work well in this dish?

Bell peppers and red onion add nice flavor and crunch. You can also include mushrooms, spinach, diced tomatoes, or black olives. Sauté watery vegetables like spinach or mushrooms before adding to prevent excess moisture.

Is the Greek yogurt dough difficult to work with?

The dough is quite forgiving and easy to handle. It may feel slightly sticky initially, so dust your hands and surface with a little flour. Kneading for just 2-3 minutes makes it smooth and manageable for pressing into the pan.

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High-Protein Pizza Breakfast Casserole

Hearty morning bake combining pizza flavors with nutritious ingredients for a protein-packed start to your day.

Prep Time
20 Minutes
Cook Time
25 Minutes
Total Time
45 Minutes


Difficulty: Easy

Cuisine: American

Yield: 6 servings

Dietary: None specified

Ingredients

Greek Yogurt Dough

01 1 cup plain Greek yogurt (2% or 0% fat)
02 1 cup self-rising flour, plus extra for dusting
03 1/2 teaspoon garlic powder
04 1/2 teaspoon dried oregano
05 1/4 teaspoon salt

Toppings

01 6 large eggs
02 1/2 cup low-fat milk
03 1 cup shredded part-skim mozzarella cheese
04 1/2 cup shredded cheddar cheese
05 1/2 cup turkey pepperoni slices
06 1/2 cup low-sugar pizza sauce
07 1/4 cup diced bell pepper (optional)
08 1/4 cup diced red onion (optional)
09 1 tablespoon chopped fresh basil or parsley (optional)
10 Salt and black pepper to taste

Instructions

Step 01

Prepare Baking Pan: Preheat oven to 400°F. Lightly grease or line a 9x13-inch rimmed sheet pan with parchment paper.

Step 02

Mix Dough Base: In a medium bowl, combine Greek yogurt, self-rising flour, garlic powder, oregano, and salt. Mix until a shaggy dough forms.

Step 03

Knead and Shape Dough: Knead dough briefly on a lightly floured surface until smooth, approximately 2 to 3 minutes. Roll or press dough into a rectangle to fit the prepared sheet pan, then transfer and press evenly to all edges.

Step 04

Layer Sauce: Spread pizza sauce evenly over the dough base in a thin, uniform layer.

Step 05

Prepare Egg Mixture: In a large bowl, whisk together eggs, milk, a pinch of salt, and black pepper until well combined and uniform.

Step 06

Add First Cheese Layer: Sprinkle half of the mozzarella and cheddar cheese over the pizza sauce layer.

Step 07

Pour Custard: Pour the egg mixture evenly over the cheese layer, distributing it across the entire surface.

Step 08

Add Remaining Toppings: Top with turkey pepperoni, remaining cheese, bell pepper, and red onion if using.

Step 09

Bake Casserole: Bake for 22 to 25 minutes, or until eggs are set and cheese is golden and bubbly.

Step 10

Rest and Serve: Remove from oven and allow to cool for 5 minutes. Garnish with fresh basil or parsley if desired. Slice and serve warm.

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Tools You'll Need

  • Mixing bowls
  • Whisk
  • Rolling pin
  • 9x13-inch sheet pan
  • Parchment paper
  • Knife and cutting board

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains wheat (gluten)
  • Contains eggs
  • Contains milk (dairy)
  • Check pepperoni, cheese, and pizza sauce labels for additional allergens or additives

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 270
  • Total Fat: 12 g
  • Total Carbohydrate: 20 g
  • Protein: 20 g

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